Endocrine Abstracts

The mechanisms that lead to tumor formation of and aldosterone secretion by zona glomerulosa cells in primary aldosteronism are not known. Recently, endothelial cell-derived factors have been characterized that control the release of aldosterone by adrenocortical cells. In addition, we started to characterize the regulation of CITED2, a CBP/p300 interacting transactivator with ED-rich tail 2. Earlier, it was shown in mice that absence of CITED2 leads to adrenal agenesis. Since...